89% of PMDD patients experience more functional days after 12-week lifestyle intervention
First Dutch pilot study on structured lifestyle interventions for Premenstrual Dysphoric Disorder
This pilot study evaluates the effectiveness of a 12-week lifestyle program for women with PMDD. The program combines international evidence-based guidelines with practical insights from over 50,000 community-reported experiences.
Key Results
After 12 weeks of participation, significant improvements were measured across multiple domains:
More functional days
24 of 27 participants reported significant increase
Symptom reduction
DRSP score decreased from 5.3 to 4.2
Less sick leave
From 4.5 to 1.7 sick days per month
Net Promoter Score
Average recommendation score
Detailed Results per Domain
| Domain | Baseline | After 12 weeks | Improvement |
|---|---|---|---|
DRSP Symptom Score Daily Record of Severity of Problems (validated) | 5.3 / 6 | 4.2 / 6 | -21% |
Sick Leave Days Self-reported work participation | 4.5 days/month | 1.7 days/month | -62% |
Quality of Life Based on SF-12 questionnaire | 2.0 / 5 | 4.0 / 5 | +100% |
Crisis Preparedness Confidence in symptom management | 1.8 / 5 | 4.2 / 5 | +133% |
Functional Days 24 of 27 participants reported improvement | Variable | Significant ↑ | +89% |
Program Completion 5 stopped early (2 with sufficient tools) | 27 participants | 22 completed | 81% |
Participant Feedback
The overview of lifestyle adjustments was my breakthrough. I finally understand what works and what doesn't for me — and I recognize myself again.
— Participant, 29 years, HR professional
The program offered valuable support during the long wait for specialist care. I no longer felt alone.
— Participant, 34 years, Finance
The structured approach gave me back control. For the first time in years, I feel in charge of my own life.
— Participant, 38 years, Education
Key Findings
- Bridging wait time: The program offered valuable support during wait time for specialist care
- Identity restoration: Participants reported "recognizing themselves again" and experiencing more control
- Structure and overview: The structured approach to lifestyle adjustments was highly valued
- Community and recognition: Contact with peers reduced feelings of isolation
Societal Impact
PMDD affects an estimated 5-8% of menstruating women — approximately 1 in 20 women. The average time to diagnosis is 12-20 years.
Women has PMDD
Approximately 400,000 women in Netherlands
Average time to diagnosis
Women visit 6+ healthcare providers
Annual cost per patient
Due to sick leave and healthcare consumption
Methodology
This was a prospective cohort study with validated instruments. Participants were measured at baseline (T0), week 6 (T1), week 12 (T2), and 3-month follow-up (T3). The program combines international clinical guidelines (RCOG, IAPMD) with systematic analysis of 50,000+ community experiences.
Follow-up Research
Based on these promising results, a digital platform is being developed with 24/7 support, personalized recommendations, and integration with healthcare providers.
This program is not a replacement for medical treatment. It is developed as complementary support for lifestyle adjustments. Results subject to peer review.
Interested in collaboration?
Schedule an introduction call to discuss how we can support patients together.
No obligations • 30 minute introduction